Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation
Status:
Terminated
Trial end date:
2000-09-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Bone marrow transplantation may be able to replace immune cells that were
destroyed by chemotherapy or radiation therapy used to kill tumor cells. Sometimes the
transplanted cells from a donor can make an immune response against the body's normal cells.
Eliminating the T cells from the donor cells before transplanting them may prevent this from
happening.
PURPOSE: Phase II trial to study the effectiveness of T cell removal to prevent
graft-versus-host disease in patients who are undergoing bone marrow transplantation from a
donor.
Phase:
Phase 2
Details
Lead Sponsor:
H. Lee Moffitt Cancer Center and Research Institute