Renal Protection of Intravenous Dexmedetomidine During Radical Cystectomy

• Status: Completed
• Trial end date: 2020-08-30
• Target enrollment: 0
• Participant gender: All

Summary

Acute kidney injury and chronic kidney disease usually associated with radical cystectomy operation which is the treatment of choice for invasive urinary bladders tumor. Peri-operative acute kidney injury (AKI) is common but poorly recognized and managed which is associated with increase surgical morbidity and mortality and hospital cost .Prospective human studies establishing a renal protective effect of dexmedetomidine are still questionable.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Dexmedetomidine; Fentanyl

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists physical status I or II.

• Patients scheduled for elective radical cystectomy.

Exclusion Criteria:

• Serum creatinine level equal or greater than 1.4 mg/dl.

• Allergy to alpha-2 adrenergic agonist

• Allergy to any anesthetic drugs

• Uncontrolled hypertension.

• Uncontrolled diabetes.

• Heart block greater than first degree.

• History of alcohol abuse.

• History of drug abuse.

• Clinically significant neurologic disease.

• Clinically significant cardiovascular disease.

• Clinically significant respiratory disease.

• Clinically significant hepatic disease.