Renal Response to Lower Body Negative Pressure in Pre-hypertensive States

• Status: Completed
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to orthostatic stress.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: PD Dr. Grégoire Wuerzner
• Collaborator: Swiss National Science Foundation
• Treatments: Candesartan; Candesartan cilexetil

Criteria

Inclusion Criteria:

• BMI > 30 Kg/m2 (obesity group)

• office BP >140/90 and daytime ambulatory blood pressure <135/85 (white coat hypertension group) _daytime abpm >135/85 mm Hg or nighttime abpm 120/70

Exclusion Criteria:

• History of allergic reaction

• Diabetes type 1 or type 2

• History of renal artery stenosis

• Acute illness