Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension

• Status: Completed
• Trial end date: 2005-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Plasma renin values determine whether volume or vasoconstrictor (renin) factors predominate in elevating blood pressure and are useful in selecting effective antihypertensive therapy.2,3

The researchers hypothesize that:

1. Plasma renin-guided therapeutics will improve systolic and diastolic blood pressure control in patients with untreated hypertension as well as in patients with treatment refractory or resistant hypertension that are managed by Clinical Hypertension Specialists.

2. Renin-guided therapeutics will reduce the number of medications required to maintain blood pressure control to <140/90 mmHg in hypertensive patients receiving 3 or more medications, while under the care of a Clinical Hypertension Specialist.

3. Renin-guided therapeutics selection will reduce the total cost of antihypertensive care provided by Clinical Hypertension Specialists.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical University of South Carolina
• Collaborator: New York Presbyterian Hospital
• Treatments: Antihypertensive Agents; Coal Tar; Hydrochlorothiazide

Criteria

Inclusion Criteria:

• Age, 21 years of age and older

• Male or female (post-menopausal or effective method of birth control)

• BP and treatment criteria noted above

• Willingness to provide written, informed consent

• Ability to adhere to study protocol

Exclusion Criteria:

• Uncontrolled diabetes or hyperlipidemia requiring medication changes

• Any active disease process requiring new diagnostic and therapeutic plans

• Any life-threatening illness

• History of alcohol or drug abuse in past 5 years

• Mental illness or personality disorder that interfere with adherence to study protocol

• Serum creatinine >2.5 mg/dL unless documented stable for at least one year

• Dialysis for chronic renal failure, even if creatinine stable for at least one year

• Intolerance to two or more classes of antihypertensive medications

• Normal home BP (<140/90 mmHg at baseline), i.e., office only hypertension.