Repeat Dose Steroid to Prevent Pain Relapse After Total Knee Arthroplasty in Patients With High Pain Response
Status:
Recruiting
Trial end date:
2024-07-01
Target enrollment:
Participant gender:
Summary
The aim of the study is to compare the effect of a repeat moderate dose of glucocorticoids
postoperatively after preoperative high dose upon postoperative pain after Total Knee
Arthroplasty (TKA) in an High Pain Respondes (HPR) population to a standard single high dose
systemic preoperative administration in an HPR population.
As a standard procedure, all patients referred to the outpatient clinic due to suspected
degenerative knee disease will be asked to fulfill the Pain Catastrophizing Scale (PCS). If
TKA is decided, patients with a PCS score above 20 will be treated with intravenously
administered Dexamethasone 1 mg/kg as a rounded-up-dose to closest 10 mg according to our
guideline for FAST-TRACK TKA.
The repeat-dosing group (RDG) will receive a dose of 24 mg dexamethasone tablets at 9-11 pm
on the first postoperative day. The control-group (CG) will receive placebo tablets at 9-11
pm on the first postoperative day.