Rescue Emetic Therapy for Children Having Elective Surgery
Status:
Withdrawn
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
To compare ondansetron, metoclopramide, diphenhydramine, and placebo in order to determine
which anti-emetic is most efficacious as a "rescue therapy" for pediatric patients ages 3-18
who have post-operative vomiting after a standardized prophylactic regimen of ondansetron and
dexamethasone. We hypothesize that anti-emetics with a different mechanism of action than the
prophylactic regimen will be the most effective "rescue therapy" in children having surgery
in an ambulatory surgery center.
1. Problem: Despite commonly-used anti-emetics for prophylaxis, some children still go on
to develop post-operative vomiting (POV).
Goal: To determine which anti-emetic--ondansetron, metoclopramide, diphenhydramine, or
placebo--is most efficacious for pediatric patients in this situation.
2. Hypothesis: Anti-emetic medications that have a different mechanism of action than the
prophylactic regimen will be the most efficacious "rescue therapy."
3. Hypothesis: Metoclopramide at the dose of 0.5 mg/kg (max dose 20 mg) will be more
effective than ondansetron, diphenhydramine, or placebo as "rescue therapy."