Research Study for Children With Salt Wasting Congenital Adrenal Hyperplasia

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to develop a more physiological approach to the management of children and adolescents with salt wasting Congenital Adrenal Hyperplasia.

We will administer the glucocorticosteroid via insulin infusion pump to see whether this treatment will improve the serum hormone concentrations.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Baylor College of Medicine
• Treatments: Cortisol succinate; Epinephrine; Epinephryl borate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Hydrocortisone hemisuccinate; Racepinephrine

Criteria

Inclusion Criteria:

• Children with salt wasting CAH otherwise healthy without other chronic disease

• Age: between 3 and 18 years of age

• Body weight 23 kg (50 lbs) or above

• Hemoglobin equal to or higher than 12 g/dl before the study

• Supportive family environment

Exclusion Criteria:

• Age less than 3 or older than 18 years at the time of study

• Other chronic disease

• Hemoglobin less than 12 g/dl

• Non-supportive family

• Allergy to local anesthetics

Criteria for study termination: If the subject's parents are unable to manage/operate the pump, the subject will be withdrawn from the study.