Research of Intensive Metabolic Intervention Before Pregnancy in PCOS

• Status: Unknown status
• Trial end date: 2020-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

To investigate whether intensive metabolic intervention of PCOS women before pregnancy can improve pregnancy outcome.Besides, the investigators aim to investigate the best therapy strategy of metabolic intervention before pregnancy.The investigators plan to recruit PCOS women at childbearing age. By using acarbose, GLP-1 analogue, berberin et al. the investigators will intervent the participants' metabolic statues for 3 months before pregnancy and to compare outcome in each group.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RenJi Hospital
• Treatments: Acarbose; Exenatide; Metformin; Orlistat

Criteria

Inclusion Criteria:

• PCOS women at Childbearing Age

• PCOS: Clinical hyperandrogenism and/or hyperandrogenemia, menstrual dysfunction (oligomenorrhea or amenorrhea) and exclusion of other known disorders. PCOS will be diagnosed using the 2003 Rotterdam criteria.

Exclusion Criteria:

• Past or present history of a medical disorder or medication known to affect body composition, insulin secretion and sensitivity, or the growth hormone (GH)-insulin-like growth factor 1 (IGF1) axis (eg steroid hormone or thyroid replacement).

• History of current or past pregnancy

• Hormonal contraceptive or metformin use within 3 months of enrollment

• Nonclassical congenital adrenal hyperplasia