Research on Effect of Traditional Chinese Medicine (TCM) on Immune Reconstitution of HIV/AIDS Patients After Highly Active Antiretroviral Therapy (HAART)

• Status: Unknown status
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Chinese prescriptions can inhibit viral replication according to the course of viral replication, and the effects is similar to the effect of HAART, and even better than the anti-viral and immune reconstitution of HAART due to its effect on improve immune system function. Over the past decades, many researchers have screened the effective Chinese medicines to treat AIDS.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Criteria

Inclusion Criteria:

• HIV antibody-positive, confirmed by Western Blot test

• HIV antibody-positive, confirmed by Western Blot test

• HAART ≥ 12 months

• CD 4 count increased by <100 cells / ul

• HIV RNA <50 c / ml (bDNA);

• Age ≥ 18 years old and ≤ 70 years old

• Voluntary participated in this study, signed informed consent form, and could be followed-up

Exclusion Criteria:

• Serious opportunistic infections were not brought under control (Pneumocystis carinii pneumonia, meningitis, esophageal candidiasis, lymphoma, toxoplasma encephalopathy, tuberculosis, etc.) before the experiment

• Participated in clinical trials of other drugs within one month before the experiment

• Received immunomodulatory treatment within one month before the experiment

• WBC <2 × 10 9 / L, N <1.0 × 10 9 / L, Hb <90g / L, PLT <75 × 10 9 / L,liver and kidney dysfunction (AST, ALT, T-BIL ≥2 times of upper limit of the reference value or creatinine ≥ 2 times of the upper limit of reference value)

• Patients with pancreatitis or active gastric ulcer

• Patients with obvious active diseases in respiratory system, digestive system, circulatory system, blood system, neuroendocrine system, or genitourinary system diseases

• Persons suffering from autoimmune diseases

• Cancer patients which need chemotherapy

• Pregnant or lactating women, and did not use safe contraceptive measures for women of child-bearing age, as well as the male that can not take a reasonable method of contraception in trial period

• Hypersensitive people

• Patients with dysgnosia or language barriers, which can not fully understand the test or cooperate well