Research on Translational Outcomes of Alcohol (Project RETRO)

• Status: Not yet recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of the current study is to assess the effect of a single dose of carbidopa-levodopa on ad libitum alcohol consumption and alcohol craving in young adults with a history of binge drinking.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Washington
• Treatments: Carbidopa; Carbidopa, levodopa drug combination; Levodopa

Criteria

Inclusion Criteria:

• Enrolled in 2- or 4-year college program

• Currently living in the Seattle Metropolitan area

• Have at least two or more episodes of heavy episodic drinking (4/5 or more drinks in a 2 hours for women/men) in the past 30 days.

Exclusion Criteria:

• Exclusion criteria include:

• past-month severe alcohol or other substance use disorders,

• mood or anxiety disorder

• suicidal ideation

• risk of psychotic disorders

• excessive alcohol use reaching a Blood Alcohol Level greater than .30%

• history of serious medical conditions, regular use of prescription psychotropic or pain medication

• history of negative reactions to alcohol

• history of treatment for alcohol use disorder

• pregnancy or nursing.

• use of non-selective monoamine oxidase inhibitors in the past 2 weeks.

• narrow-angle glaucoma

• undiagnosed skin lesions,

• have a history of melanoma, cardiac issues or peptic ulcer.

• Currently taking or prescribed any form of levodopa or D2 agonists, D2 antagonists, isoniazid, methylphenidate, bupropion, Viagra, or phosphodiesterase inhibitors.