Respiratory Effects of Dopamine in the Perioperative Care
Status:
Active, not recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
Dopamine is frequently used as an inotropic drug to elevate cardiac output. In addition to
the beneficial cardiac effect of this drug, the few previous studies addressing its ability
to alter the airway tone reported controversial results.
Thus, the investigators aimed at clarifying the potential of dopamine to alter gas exchange
outcomes and the airway tone in patients undergoing cardiac surgeries with cardiopulmonary
bypass.
Blood gas parameters, airway resistance, tissue damping and tissue elastance will be measured
in the patients before the CPB, immediately after CPB, and 5 min after administration of
dopamine (3 mcg/kg/min).
The importance of the research is to reveal whether the beneficial mechanical changes after
dopamine administrations are associated with improvements in gas exchange outcomes.
Clarification of this research question have scientific relevance and may also improves
patient outcomes.