Respiratory Impedance and Obliterative Bronchiolitis
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
The aim of the present study will be to test the hypothesis that changes in within-breath
total respiratory input impedance (Zrs) may provide an early evidence of obliterative
bronchiolitis after allogeneic hematopoietic stem cell transplantation (HSCT). Before and
after HSCT, Zrs will be measured by a modified forced oscillation technique (FOT) during
spontaneous breathing both at baseline and 30 min after albuterol inhalation . Such technique
may be particularly sensitive to small changes in lung mechanics observed in the early stages
of peripheral airflow obstruction.
Phase:
N/A
Details
Lead Sponsor:
IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy