Respiratory Impedance and Obliterative Bronchiolitis

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study will be to test the hypothesis that changes in within-breath total respiratory input impedance (Zrs) may provide an early evidence of obliterative bronchiolitis after allogeneic hematopoietic stem cell transplantation (HSCT). Before and after HSCT, Zrs will be measured by a modified forced oscillation technique (FOT) during spontaneous breathing both at baseline and 30 min after albuterol inhalation . Such technique may be particularly sensitive to small changes in lung mechanics observed in the early stages of peripheral airflow obstruction.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
• Treatments: Albuterol

Criteria

Inclusion Criteria:

• consecutive, clinically-stable, outpatients undergoing allogeneic HSCT (sourcing from bone marrow) for hematological malignancies

• values of standard PFTs within normal range before HSCT

• good collaboration during the maneuvers

Exclusion Criteria:

• patients showing any spirometric and/or volumetric abnormality before HSCT

• poor collaboration and/or coordination during the maneuvers

• any clinically-significant respiratory disease (bronchial asthma, COPD, cystic fibrosis, etc.) before HSCT