Responsiveness Index Versus the RASS Based Method for Adjusting Sedation in Critically Ill Patients
Status:
Completed
Trial end date:
2017-08-28
Target enrollment:
Participant gender:
Summary
Systematic evaluation of pain, agitation and delirium in ICU-patients is recommended and deep
sedation should be avoided. Sedation is still monitored with clinical assessments, like RASS.
The Responsiveness Index (RI) is a recently described method for ICU sedation monitoring. It
is based on processed frontal EMG and reflects the interaction between a patient's conscious
state and the intensity and frequency of stimulations during treatment. RI has not been
randomly compared to RASS to titrate sedation to target at a clinically adequate sedation
state. In this open randomized controlled pilot study of 32 critically ill, mechanically
ventilated adult patients, investigators will evaluate the feasibility, safety and efficacy
of RI based sedation compared to standard RASS based titration of sedation. Investigators
hypothesize first that RI controlled sedation will be safe and, second that RI controlled
sedation will associate with increased number of ventilator free days alive in 30 days
without excess adverse events.