Responsiveness of Exercise Tests in Pulmonary Arterial Hypertension

• Status: Completed
• Trial end date: 2011-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Pulmonary arterial hypertension (PAH) is characterized by the progressive increase in pulmonary vascular resistance leading to shortness of breath and exercise intolerance. Exercise capacity has been used as the primary endpoint in most recent randomized controlled trials evaluating PAH-specific therapies as it correlates with functional class and survival in PAH. Exercise test is commonly assessed by the six-minute walk test (6MWT). However, there is commonly some discrepancy between significant clinical improvement and minor changes (generally <10% from baseline) in 6WMT following therapy. Because important clinical decisions are based on patients' functional capacity, a reproducible and sensitive exercise test is needed in PAH. The aim of this study was to compare the reproducibility and the responsiveness of the 6MWT, the endurance shuttle walk test (ESWT) and the cycle endurance test (CET) following pharmacological therapy in this disease.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Laval University
• Treatments: Sildenafil Citrate

Criteria

Inclusion Criteria:

• WHO functional class II or III

• Idiopathic PAH, familial PAH, or associated PAH due to connective tissue disease patients

• Mean pulmonary artery pressure ≥25 mmHg at rest

• Pulmonary capillary wedge pressure ≤15 mmHg

Exclusion Criteria:

• Prior use of phosphodiesterase type-5 inhibitors

• Unstable clinical condition over the last 4 months

• Recent syncope

• WHO functional class IV

• Left ventricular ejection fraction <40%

• Restrictive or obstructive lung disease

• Intrinsic musculoskeletal abnormality precluding exercise testing

• Patients with a pacemaker

• Treatment with systemic corticosteroids