Resuscitation With Albumin 5% in Dengue Haemorrhagic Fever
Status:
Unknown status
Trial end date:
2019-09-01
Target enrollment:
Participant gender:
Summary
Endothelial cell had important role in plasma leakage process. Plasma leakage occurs due to
increased vascular permeability caused by disruption of endothelial glycocalyx showed by
increased syndecan-1 level in serum. Endothelial vascular permeability disruption may cause
several clinical manifestations such as increased haematocrit level, pleural effusion,
ascites, hypoalbuminemia, thrombocytopenia, and bleeding manifestation. This condition will
lead to hypoperfusion in the tissue and microvascular dysfunction. Microvascular dysfunction
activated anaerob mechanism and resulting increased lactate level serum. Severe dysfunction
can lead to shock and death if fluid resuscitation is inadequate in the first 24 hour.
Fluid administration becomes key therapy for plasma leakage. Crystalloid is an isotonic fluid
which can fill intravascular, however this fluid also quickly moved toward extravascular.
Albumin 5% can help reduce the extravasation because of it can increase the osmotic pressure
and maintaining the intravascular volume. In the first 24 hour after albumin administration,
albumin is hypothesized can restore intravascular volume, repair and maintain glycocalyx,
maintain vascular permeability, and restore microcirculation perfusion. This mechanisms can
prevent worse outcome and hoped can reduce hospital stay.
Many studies had been done regarding the choice of resuscitation fluid in septic patient.
Until now, the role of albumin 5% as resuscitation fluid in DHF to prevent severe plasma
leakage has not been studied.