Resveratrol and Human Hepatocyte Function in Cancer

• Status: Withdrawn
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if Resveratrol, a nutritional supplement, shows a beneficial effect in the cellular function of normal liver cells and diseased liver cells (cancer cells) in samples of liver tissue taken during elective liver surgery. Outcomes based on 3 measures will test the hypothesis that Resveratrol when used as a nutritional supplement will 1)improve metabolic function in liver cells, 2)reduce cellular growth and proliferation of cancer cells, 3)decrease inflammation in the liver.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Louisville
• Treatments: Resveratrol

Criteria

Inclusion Criteria:

• Undergoing elective liver resection for liver cancer

Exclusion Criteria:

• Inability to speak or read English

• Sclerosing cholangitis, hemochromatosis, hepatic encephalopathy, acute hepatic failure

• History of daily alcohol intake

• Presence of human immunodeficiency virus

• Presence of significant renal dysfunction as defined by baseline serum creatinine > 2.0 mg/dl or need/impending need for chronic dialysis therapy

• Known allergy to the study medication

• Pregnancy, lactating women, women contemplating pregnancy during the study period