Resveratrol in Knee Osteoarthritis

• Status: Recruiting
• Trial end date: 2022-05-09
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether resveratrol is effective in the treatment of painful knee osteoarthritis.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborators: Unité de Recherche Clinique (URC) Paris Descartes Cochin; URC-CIC Paris Descartes Necker Cochin
• Treatments: Resveratrol

Criteria

Inclusion Criteria:

• Age ≥ 40 years-old

• Knee osteoarthritis fulfilling 1986 American College of Rheumatology (ACR) criteria

• Pain on numeric rating scale ≥ 40/100

• Symptom duration ≥ 1 month

• Kellgren and Lawrence X-Ray score 1, 2 or 3

• Written consent obtained

• Health insurance cover

Exclusion Criteria:

• History of symptomatic crystal or inflammatory arthritis

• Knee surgery ≤ 1 year

• Knee trauma ≤ 2 months

• Knee intra-articular injections of corticosteroids and/or hyaluronic acid ≤ 2 months

• Neurologic disorders involving the lower limbs

• Patient not understanding and not speaking french

• Participation in another biomedical research

• Contraindication to resveratrol or hypersensitivity to any of its constituents

• Current use of intramuscular, intravenous or oral corticosteroids

• Uncontrolled diseases that may require intramuscular, intravenous or oral corticosteroids

• Current use of anticoagulants