Retarded Phosphatidylcholine in Steroid-Dependent Chronic Active Ulcerative Colitis
Status:
Completed
Trial end date:
2006-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate if retarded release phosphatidylcholine is an
effective alternative to steroid dependent or -refractory course in chronic active ulcerative
colitis.
The hypothesis is, that ulcerative colitis is caused by a barrier defect of the colonic mucus
layer. The background of the study is the finding, that the phosophatidylcholine content of
the colonic mucus is strongly reduced in ulcerative colitis (UC) compared to healthy controls
and patients with Crohn´s disease. The content was measured in non-inflamed areas of the
colon in UC. Thus, we evaluate whether a substitution of colonic PC is an effective method
for steroid dependent UC. See: Gut. 2005 Jul;54(7):966-71. Stremmel et al.