Revascularisation or Medical Therapy in Elderly Patients With Acute Anginal Syndromes

• Status: Completed
• Trial end date: 2019-12-12
• Target enrollment: 0
• Participant gender: All

Summary

For octogenarian patients with NSTEMI (non-ST segment elevation myocardial infarction) an invasive-guided strategy will prove superior to a conservative strategy with respect to a combined endpoint of all cause mortality and non-fatal myocardial infarction.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brighton and Sussex University Hospitals NHS Trust
• Collaborator: Medtronic Vascular
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Bisoprolol; Clopidogrel; Dalteparin; Heparin; Heparin, Low-Molecular-Weight; Ramipril; Tinzaparin

Criteria

Inclusion Criteria:

• AGE>80 Non-STEMI - characteristic chest pain accompanied by

• Typical ischaemic ECG changes

• A troponin rise

Suitable for conservative or invasive strategy

Exclusion Criteria:

• Lack of suitability for whatever clinical reason to be randomised eg dementia, co-morbidity

• Acute STEMI

• Cardiogenic shock

• Platelet count =50 x 109/mm3

• Patient life expectancy < 1 year

• Known allergies to clopidogrel, aspirin, heparin, stainless steel, IV contrast or stent drug elutant

• Recent major GI haemorrhage (within 3 months)

• Any previous cerebral bleeding episode

• Participation in another investigational drug or device study

• Patient unable to give consent

• Clinical decision precluding the use of stents