Reversing Glucose and Lipid-mediated Vascular Dysfunction

• Status: Not yet recruiting
• Trial end date: 2024-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Kansas Medical Center
• Treatments: Ascorbic Acid; Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria:

• Lean: BMI < 25 kg/m

• Normal insulin sensitivity: (calculation based on fasting glucose and insulin concentrations in blood)

• Middle-aged: 18-79 years

• Blood pressure: < 140 (systolic) and < 90 mmHg (diastolic

• Weight stable (+/- 5 lbs) for the previous 3 months

• Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior.

• Able and willing to provide written informed consent

Exclusion Criteria:

• Diabetes mellitus Type I or Type II: fasting glucose < 126 mg/dL and/or HbA1c < 6.5%

• Current smoker or History of smoking in the past 3 months.

• Hyperlipidemia: Fasting triglycerides < 250 mg/dL

• Hypertension: >130/80 mmHg

• History of heart disease (e.g., myocardial infarction, stent, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)

• History of vascular disease (e.g., bypass, stroke)