Overview

Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection

Status:
Recruiting
Trial end date:
2028-03-01
Target enrollment:
Participant gender:
Summary
In this Dutch multicenter clinical trial, patients with a staphylococcal prosthetic joint infection, will, in the oral antibiotic treatment phase, be randomized between clindamycin monotherapy and rifampicin / levofloxacin combination therapy. The clinical endpoint will be treatment success one year after finishing antimicrobial treatment.
Phase:
Phase 4
Details
Lead Sponsor:
Leiden University Medical Center
Collaborators:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Alrijne Hospital
Elisabeth-TweeSteden Ziekenhuis
Erasmus Medical Center
Isala
Martini Hospital Groningen
Medical Centre Leeuwarden
Onze Lieve Vrouwe Gasthuis
Radboud University Medical Center
Reinier Haga Orthopedisch Centrum
Rijnstate Hospital
Sint Maartenskliniek
Spaarne Gasthuis
Tergooi Hospital
University Medical Center Groningen
Treatments:
Clindamycin
Clindamycin palmitate
Clindamycin phosphate
Levofloxacin
Rifampin