Rifaximin and Misoprostol Combination Therapy for Healing of Small Bowel Ulcers in Aspirin Users
Status:
Recruiting
Trial end date:
2023-06-30
Target enrollment:
Participant gender:
Summary
Background: Investigators have previously shown that misoprostol can heal small bowel ulcers
in aspirin users with small bowel bleeding. However, the rate of small-bowel mucosal healing
was low with use of misoprostol alone. There is evidence to suggest that bacteria contribute
to the development aspirin-induced ulcers and antibiotics may be useful in its treatment.
Rifaximin, a non-absorbed oral antibiotic that target the gastrointestinal tract have been
shown to be safe and effective in a few other gastrointestinal conditions.
Small bowel capsule is the most sensitive and non-invasive way to investigate the small
bowel. It plays an important role in obscure GIB investigations.
Aims: The aim of this randomized study is to test the hypothesis that misoprostol combined
with rifaximin is superior to misoprostol alone for healing of small bowel ulcers in aspirin
users complicated by small bowel bleeding.
Study design: 8-week double-blind randomized trial