Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA
Status:
Completed
Trial end date:
2020-02-01
Target enrollment:
Participant gender:
Summary
The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea
(OSA) in the same patient has been termed overlap syndrome, affecting 1% of the U.S.
population.The investigators propose to conduct this study that aims: (1) to compare right
and left ventricular hemodynamic parameters using cardiac magnetic resonance imaging (MRI) in
overlap syndrome vs. COPD only and OSA only; (2) to compare the effects of bi-level positive
airway pressure (BPAP) vs. nocturnal oxygen therapy (NOT) on right ventricular (RV)
hemodynamics in overlap syndrome.
This study will allow us to test the hypothesis: (1) Patients with overlap syndrome have more
RV dysfunction than those with COPD only or OSA only; (2) treatment of both hypoxemia and
hypercapnia during sleep will improve RV hemodynamics compared with treatment of hypoxemia
alone in patients with overlap syndrome.