Risperidone vs. Olanzapine as add-on Treatment in Treatment Resistant Depression
Status:
Completed
Trial end date:
2004-03-01
Target enrollment:
Participant gender:
Summary
Atypical neuroleptics may have antidepressant qualities in bipolar depression and in unipolar
depression. Some data support the use of both Risperidone and Olanzapine, but there are no
direct comparisons of their relative efficacy and tolerability in treatment resistant
depression. The current study was designed as a pilot study to examine efficacy and
tolerability of Olanzapine vs. Risperidone add on to a failed serotonin re-uptake inhibitor
(SSRI) in depression.