Rituximab With or Without Ibrutinib for Patients With Advanced Follicular Lymphoma
Status:
Active, not recruiting
Trial end date:
2029-12-01
Target enrollment:
Participant gender:
Summary
Follicular lymphomas FL has been traditionally approached either by an initial watch and wait
policy in the asymptomatic patient, or with single agent treatments with the purpose of
maintaining a good quality of life for a prolonged time.The combination of rituximab and
ibrutinib has been tested in clinical trials and appeared to be well tolerated and active.
Since ibrutinib seems to achieve better results when administered for prolonged time as shown
in CLL, the investigators have chosen to compare its combination with rituximab to the
prolonged rituximab-only schedule that was already shown to be very active in the SAKK 35/03
trial.
The aim of the study is to investigate the efficacy, safety and tolerability of the treatment
combination of Ibrutinib and Rituximab for patients with advanced follicular lymphoma in need
of therapy.