Rituximab and Combination Chemotherapy in Treating Patients With Primary Central Nervous System Lymphoma
Status:
Terminated
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different
ways. Some find cancer cells and kill them or carry cancer-killing substances to them. Others
interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy,
such as methotrexate, leucovorin, vincristine, procarbazine, dexamethasone, and cytarabine,
work in different ways to stop the growth of cancer cells, either by killing the cells or by
stopping them from dividing. Giving rituximab together with combination chemotherapy may kill
more cancer cells.
PURPOSE: This phase II trial is studying how well giving rituximab together with combination
chemotherapy works in treating patients with primary central nervous system (CNS) lymphoma.