Until now there ist no systematic investigation of the pharmacokinetic parameters of
Rivaroxaban in obese patient undergoing bariatric surgery. The aim of this study is to
investigate the pharmacokinetic and pharmacodynamic parameters of rivaroxaban in obese
patients before and after bariatric surgery.
Patients receive the day before the surgical intervention the first dose of Rivaroxaban
(10mg). During the following 24 hours, 9 blood samples are taken.
The second tablet Rivaroxaban is administered on the third postoperative day, followed again
by 9 blood samples during the next 24 hours.
All other blood samples are taken independent from this clinical trial as part of the
standard medical treatment during the hospitalization. The hospital stay will not be extended
by the study. The outpatient regular follow-up takes place one month after surgery and is
combined with the last study visit.