Rocuronium Dose Finding Study After Single-shot or Steady-state Propofol Anesthesia

• Status: Completed
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed to determine the effective-doses ED-50 and ED-95 (the doses required for a 50% and 95% twitch inhibition, respectively) of the non-depolarizing muscle relaxant rocuronium after single-shot or steady-state propofol anesthesia in a clinical setting.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Technische Universität München
• Treatments: Propofol; Remifentanil; Rocuronium

Criteria

Inclusion Criteria:

1. Patients scheduled for a low risk-surgical procedure under general anesthesia

2. Patients ASA physical status I-III

3. Patients older than 18years

4. Patients having given informed consent to the study

Exclusion Criteria:

1. Patients who decline to give informed consent to the study

2. Known or suspected allergy towards anesthetics or rocuronium

3. Pregnant and breastfeeding women

4. Known or suspected neuromuscular disease

5. Burn injury prior to the investigation

6. Anatomic and functional malformations with expected difficult intubation

7. Anorexia, Bulimia nervosa, Malnutrition

8. Heart failure

9. Use of drugs that interfere with muscle relaxant