Role Of Dexamethasone In Induction Of Labor

• Status: Unknown status
• Trial end date: 2019-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

Research hypothesis :

In pregnant women undergoing induction of labor, intramuscular injection of dexamethasone may accelerate induction delivery interval.

Research question :

In pregnant women undergoing induction of labor, does intramuscular injection of dexamethasone accelerate induction delivery interval ?

This study aims to assess the effect of intramuscular administration of dexamethasone on the induction delivery interval in full term patients undergoing induction of labor.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

1. Primipara.

2. Gestational age (39-41) weeks according to Naegele's rule and a first-trimester ultrasound evaluation.

3. Vertex presentation.

4. Singleton fetus.

5. Intact fetal membranes.

6. No contraindication for vaginal delivery.

7. Cervix with a poor Bishop score (4-6).

8. Reactive CTG.

9. Average amount of liquor.

Exclusion Criteria:

1. Indication for cesarean section e.g. CPD, Placenta previa, IUGR, Non vertex presentation and previous cesarean section.

2. Maternal medical disorders as diabetes mellitus and severe pre-eclampsia.

3. Active phase of labor (cervical dilatation of 4 cm plus 3 forceful contractions over a ten minute span).

4. Preterm labor and premature rupture of membranes.

5. Multiparous women.

6. Significant vaginal bleeding. Placenta previa, probable placental abruption.

7. Fetal macrosomia>4.5 kg estimated by u/s.

8. Multiple pregnancy.

9. Fetal Distress and Non-reactive CTG.

10. Oligohydramnios.

11. IUGR.