Role of 200 mg Versus 400mg Vaginal Progesterone in Prevention of Preterm Labor in Twin Gestation

• Status: Recruiting
• Trial end date: 2022-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of the present study is to evaluate the effectiveness of two doses of vaginal progesterone(200mg versus400mg) and placebo in improving gestational age in twin pregnancy and its subsequent impact on perinatal outcome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aswan University Hospital
• Treatments: Progesterone

Criteria

Inclusion Criteria:

• Women pregnant in dichorionic twins.

• Transvaginal sonographic cervical length is <25 mm at 18-22 weeks gestational age.

• No symptoms, signs or other risk factors for preterm labor.

Exclusion Criteria:

• Known allergy or contraindication (relative or absolute) to progesterone therapy.

• Monochorionic twins.

• Known major fetal structural or chromosomal abnormality.

• Intrauterine death of one fetus or death of both fetuses.

• Fetal reduction in the current pregnancy.

• Cervical cerclage in the current pregnancy.

• Medical conditions that may lead to preterm delivery.

• Rupture of membranes.

• Vaginal bleeding.