Role of Acetazolamide and Hydrochlorothiazide Followed by Furosemide in Treating Nephrotic Edema

• Status: Completed
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether using furosemide following acetazolamide is effective in treating refractory edema associated with nephrotic syndrome.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shiraz University of Medical Sciences
• Treatments: Acetazolamide; Furosemide; Hydrochlorothiazide

Criteria

Inclusion Criteria:

1. Having refractory edema due to nephrotic syndrome

2. Having GFR>60 ml/min/1.73m2

3. Being able to come for weekly visit

4. Having the minimum age of 18 years

5. Signing the informed consent form

Exclusion Criteria:

1. Hypokalemia

2. Pregnancy

3. Renal transplant

4. active malignancy or infection

5. acidosis

6. Using NSAIDs

7. Having another causes of edema including liver cirrhosis, heart failure

8. Neurologic or psychiatric problem hindering adherence to the study protocol