Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training
Status:
Withdrawn
Trial end date:
2021-07-31
Target enrollment:
Participant gender:
Summary
The overall goal of this study is to address fundamental questions regarding how the molecule
acetylcholine interacts with the sympathetic nervous system to regulate blood flow and oxygen
delivery to working skeletal muscle in young and older adults. With advancing age, blood
vessels supplying active muscle lose their ability to override sympathetic constriction,
which limits delivery of oxygen and results in fatigue. Findings from these studies will
serve as the foundation for new strategies to improve regional blood flow regulation in older
adults and clinical populations, which will increase quality of life and help to preserve
functional independence.