Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training

• Status: Withdrawn
• Trial end date: 2021-07-31
• Target enrollment: 0
• Participant gender: All

Summary

The overall goal of this study is to address fundamental questions regarding how the molecule acetylcholine interacts with the sympathetic nervous system to regulate blood flow and oxygen delivery to working skeletal muscle in young and older adults. With advancing age, blood vessels supplying active muscle lose their ability to override sympathetic constriction, which limits delivery of oxygen and results in fatigue. Findings from these studies will serve as the foundation for new strategies to improve regional blood flow regulation in older adults and clinical populations, which will increase quality of life and help to preserve functional independence.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Colorado State University
• Treatments: Acetylcholine; Adenosine; Atropine; Nitroprusside; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• age 18-35 OR 60-85

Exclusion Criteria:

• recent history of smoking

• body mass index greater than 30

• history of cardiovascular or metabolic disease, including hypertension or diabetes

• medications that may affect outcome measures, such as blood pressure medications or hormone replacement therapy

• high levels of exercise training, particularly with the forearm (such as weightlifting or rock-climbing)