Role of Adenosine in the Release of VEGF and Cytokines
Status:
Terminated
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to extend previous observations in animal models regarding the
effects of adenosine in the release of cytokines to human subjects. We intend to accomplish
this in two study protocols. In the first we will infuse intravenously adenosine and measure
the plasma levels of inflammatory cytokines. In the second one, we will use a microdialysis
technique to infuse intradermally small amounts of adenosine and will measure skin blood flow
and will take a biopsy to measure levels of mRNA for cytokines.
Phase:
Phase 1
Details
Lead Sponsor:
Vanderbilt University Vanderbilt University Medical Center