Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone

• Status: Unknown status
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine to what extent CYP2B6, CYP3A4, and MDR1 polymorphisms affect the metabolism of methadone.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Washington
• Treatments: Bupropion; Digoxin; Methadone; Midazolam

Criteria

Inclusion Criteria:

• Healthy

• Within 25% of ideal body weight

Exclusion Criteria:

• Pregnant

• A prisoner

• Enemy, non-combatant

• Smoker

• Have a history of liver disease

• Have a history of heart disease

• Have a history of drug abuse

• Currently on prescription medication