Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain

• Status: Recruiting
• Trial end date: 2023-08-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of this initial investigational study is to compare the effect of desloratadine on the inflammatory responses to heat stress in firefighters exercising in their personal protective equipment.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Victoria
• Treatments: Desloratadine

Criteria

Inclusion Criteria:

• Demonstrated willingness to participate in the study and adhere to procedures by signing a written informed consent

• Biological males aged 19-50

• Successful Physical Activity Readiness Questionnaire (PAR-Q)

• Ability to swallow core temperature capsule

• VO2Max >35 mL/kg/min

• No allergy or current dosage of H1 histamine receptor antagonists

• Participants must be in good health with no 'Category A' diseases/conditions outlined in National Fire Protection Association (NFPA) 1582 (https://www.iafc.org/docs/default-source/1vcos/vws_rrkit_nfpa-1582.pdf?sfvrsn=ca9b9f0 d_2)

Exclusion Criteria:

• Biological females

• Males below age of 19, and 51-years or older

• Unsuccessful PAR-Q

• VO2Max below 35 mL/kg/min

• Allergy to H1 histamine receptor antagonists

• Esophageal constriction (inability to swallow core temperature capsule)

• Any condition or disease listed as 'Category A' in NFPA 1582 that would disqualify a person as a firefighter.

• Current use of NSAIDS or steroid drugs (oral or nasal).

• Consumption of caffeine, nicotine, or alcohol in the preceding 12-hours.

• Dehydration (urine specific gravity over 1.030)

• Recent cold/flu (at least 7-days clear of symptom resolution)

• No use of antibiotics in preceding 14-days.

• Dosing of medication that is known to exhibit adverse reactions with desloratadine dosing.