Role of Dexamethasone in the Conservative Treatment of Chronic Subdural Hematoma
Status:
Terminated
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
Current opinion regarding the use of steroids in the treatment of chronic subdural hematomas
are mostly based on observational studies. Here we present data from a prospective randomized
pilot study of twenty chronic subdural hematoma (CSDH) patients treated with dexamethasone or
placebo for 30 days.
Twenty patients with computed tomography (CT)- or magnetic resonance imaging (MRI)-confirmed
CSDH were recruited from a single center and randomized in order to receive dexamethasone or
placebo as a conservative treatment. Patients affected to the treatment group received oral
dexamethasone 12mg/day for three weeks followed by tapering. These patients were followed for
6 months and the rate of success of conservative treatment versus placebo was measured.
Parameters such as hematoma thickness and global impression of change were also compared
before and after treatment with chi-square tests. Adverse events and complications were
documented.
Phase:
Phase 4
Details
Lead Sponsor:
Centre Hospitalier Universitaire de Québec, CHU de Québec CHU de Quebec-Universite Laval