Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI
Status:
Completed
Trial end date:
2019-04-12
Target enrollment:
Participant gender:
Summary
The purpose of this study is to look at the effect of exciting using drugs to target a
specific pathway in the body, that relies on a natural chemical the body produces called
'serotonin', in patients with spinal cord injury (SCI) during sleep. During this part of the
study participants will be asked to take buspirone (Buspar) (15-50mg per day), trazodone
(100mg per day) and a placebo in a random fashion, each for a 2 week period (drug period) of
time followed by two weeks without drugs (washout period). The drugs will not be taken all at
the same time, but each will be taken separately for two weeks followed by a night study to
look at the effect the medication/placebo pill has on the way the body responds during sleep.