Role of Epoxy-eicosatrienoic Acids in Post-occlusive Hyperemia and Thermal Hyperemia

• Status: Completed
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this proof of concept study is to assess the involvement of epoxy-eicosatrienoic acids (EETs) in post-occlusive hyperemic and thermal hyperemia responses, and the interaction between nitric oxide (NO) and EETs, using the latest methods for the study of functional microcirculation.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Grenoble
• Treatments: Fluconazole; Lidocaine; NG-Nitroarginine Methyl Ester; Prilocaine

Criteria

Inclusion Criteria:

• Age between 18 and 35 years

• Affiliated to the French social security system or beneficiary a similar regime

• In good health

Exclusion Criteria:

• Active smoker

• Pregnant, parturient, breast-feeding

• Person deprived of civil liberties by judicial or administrative measure; person under legal protection,

• Minor less than 18 years

• Within period exclusion for other clinical research studies

• Person has exceeded the annual compensation for participation in trials

• Person with active disease or with prolonged treatment, excluding oral contraceptives and paracetamol

• Asthma, urticaria, angioedema, known drug allergy