The use of herbal medicinal products is increasing enormously in recent years, mainly among
women, who use them for the most varied purposes, such as in menstrual problems, menopausal
symptoms, mood disturbances and to strengthen their bones. Most of these benefits are due to
the flavonoids present in these products. These flavonoids have anticarcinogenic, antiviral,
antioxidant and antiinflammatory activities, as well as being used in the treatment of
osteoporosis, menopausal symptoms and cardiovascular diseases . Besides the benefits from the
consumption of flavonoids, little is known about their safety and potentially harmful toxic
effects, such as mutagenicity and genotoxicity which might occur if taken in large doses .
Safety of Ginkgo biloba during pregnancy or lactation was not criticized in literature.
Roasted and raw ginkgo seed were not reported in the evidence-based medicine literature as
being either safe or contraindicated in pregnancy or lactation. A higher incidence of
postpartum hemorrhage was reported in the literature when associated with a 3-month ingestion
of Ginkgo Biloba extract. Flavonoids are components of Ginkgo biloba L. (Ginkgoaceae), a
medicinal plant widely used by the population . G. biloba has its origin in China, Korea and
Japan where its fruits and leaves have been used as food and medicine for a long time.
The extract of G. biloba (EGb) is composed of different terpene trilactones, i.e.,
ginkgolides A, B, C, J and bilobalide, many flavonol glycosides, biflavones and alkylphenols
. The major flavonoids in the extract are kaempferol, quercetin and isorhamnetin] whose
metabolites were found in the blood of rats and in human urine after oral administration of
EGb. Due to its actions as an anti-inflammatory and antioxidant, EGb has been largely used in
the treatment of Alzheimer's disease, pre-menstrual syndrome, cerebrovascular insufficiency
and peripheral arterial occlusive disease . In folk medicine, EGb is used as a vermifuge, to
induce labor, for the treatment of bronchitis, chronic rhinitis, chilblains, arthritis and
edema . The aim of this study was to evaluate the effect of oral supplementation of Ginkgo
Biloba extract on the fetal weight as well as feto-maternal blood flow in cases of
intrauterine growth restriction.