Role of Hemostatic Powder (Endo-clotTM) in Prevention of Bleeding Within High Risk Patients After ESD
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
SD has become a standard treatment of gastric neoplasm confined to mucosa(epithelium). But
after procedure, formation of iatrogenic gastric ulcer is inevitable. And Post ESD ulcer
bleeding rate reported about 5% ~ 10% of all cases. Antiplatelet or anti-coagulation
treatment might be associated higher incidence of rebleeding after ESD and iatrogenic ulcer
bigger than 40mm in size is also associated.
Though several previous study have failed to show efficacy of 2nd look EGD, but those reports
pointed out that visible vessels with current bleeding or highly suspect of recent bleeding
(Forrest type IA~IIB) was observed about 10~20% of patients. Such patients are at high risk
of bleeding.
So, Investigators hypothesize that appliance of Endo-Clot(TM) at post ESD ulcer have a
significant role of protection from gastric acidic juice and help mucosa heal earlier. Thus
visible vessels with risk of bleeding is going to be rarely observed at 2nd look EGD. And
finally this protective effect might have an effect for prophylaxis of post ESD ulcer
bleeding.