Role of Immune Responses After Acute Myocardial Infarction
Status:
Unknown status
Trial end date:
2019-07-01
Target enrollment:
Participant gender:
Summary
The fascinating role of lymphocyte subtypes in the development of coronary artery disease may
be a new strategic target for understanding and therapy of acute myocardial infarction. The
determinants of cell viability are unknown, postulating that they arise from factors not only
related to microcirculation or energy expenditure, but also to inflammatory and immune
responses. Furthermore, the intense mobilization of progenitor cells secondary to myocardial
infarction triggers large lymphocyte proliferation that colonizes plaques in development,
contributing to recurrent ischemic outcomes. This project aims to evaluate the immune and
metabolic mechanisms involved in the recovery of the ischemic myocardium and coronary disease
progression.
Phase:
Phase 4
Details
Lead Sponsor:
Federal University of São Paulo
Collaborators:
FAPESP - Fundação de Apoio à Pesquisa do Estado de São Paulo Fundação de Amparo à Pesquisa do Estado de São Paulo