Overview
Role of Inhaled Nitric Oxide in Vascular Mechanics and Right Ventricular Function
Status:
Recruiting
Recruiting
Trial end date:
2024-12-01
2024-12-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The aim of this study is to evaluate the role of nitric oxide on pulmonary vasculature and right ventricular function in postoperative cardiac surgery patients.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Fernando Suarez SipmannCollaborator:
Air Liquide SATreatments:
Nitric Oxide
Criteria
- Age > 18 years- Under controlled mechanical ventilation in passive conditions
- Presence of postoperative lung collapse (confirmed by pulmonary echocardiography and
Air test)
- Preoperative left ventricular ejection fraction (LVEF) ≥ 30%.
- Absence of hypovolemia: absence of "kissing" ventricles and/or collapsibility index of
the superior vena cava < 20%.
- Stable spontaneous heart rhythm
- Postoperative hemodynamic stability:
- Mean arterial pressure (MAP) ≥ 60 mmHg
- Central venous pressure (CVP) ≥ 10 mmHg
- Heart rate (HR) ≤ 100 bpm without tachyarrhythmias
- Lactic acid ≤ 3 mmol/L
- Single vasopressor treatment
- Norepinephrine dose ≤ 0.2 μg/kg/min, without an increase ≥ 15% in the last 30
-minutes.
Obtained informed consent