Overview

Role of Inhaled Nitric Oxide in Vascular Mechanics and Right Ventricular Function

Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
0
Participant gender:
All
Summary
The aim of this study is to evaluate the role of nitric oxide on pulmonary vasculature and right ventricular function in postoperative cardiac surgery patients.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Fernando Suarez Sipmann
Collaborator:
Air Liquide SA
Treatments:
Nitric Oxide
Criteria
- Age > 18 years

- Under controlled mechanical ventilation in passive conditions

- Presence of postoperative lung collapse (confirmed by pulmonary echocardiography and
Air test)

- Preoperative left ventricular ejection fraction (LVEF) ≥ 30%.

- Absence of hypovolemia: absence of "kissing" ventricles and/or collapsibility index of
the superior vena cava < 20%.

- Stable spontaneous heart rhythm

- Postoperative hemodynamic stability:

- Mean arterial pressure (MAP) ≥ 60 mmHg

- Central venous pressure (CVP) ≥ 10 mmHg

- Heart rate (HR) ≤ 100 bpm without tachyarrhythmias

- Lactic acid ≤ 3 mmol/L

- Single vasopressor treatment

- Norepinephrine dose ≤ 0.2 μg/kg/min, without an increase ≥ 15% in the last 30
-minutes.

Obtained informed consent