Role of Interleukin-1 in the Regulation of Muscle Derived Interleukin-6 During Exercise
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
Aim: Evaluate the regulation of muscle derived Interleukin-6 (IL-6)during exercise and in
particular whether it is regulated by the Interleukin-1 (IL-1) system.
Rationale: It has been shown that IL-1 antagonism improves glycemia and insulin secretion in
patients with type 2 Diabetes. However, IL-1 antagonism also decreases IL-6 levels. The
effect if IL-6 on the glucose metabolism has been unclear in the past and subject to intense
debate, with recent evidence indicating a beneficial role in regulating glucose metabolism.
However little is known about regulation of muscle-induced IL-6 produced during exercise. It
is therefore our aim to investigate whether exercise induced increases in IL-6 are dependent
on the IL-1 system. If IL-1 antagonism does decrease IL-6 and along with it, the beneficial
potential of IL-6, this may require additional medication like IL-6 substitution or
dipeptidyl peptidase-IV (DPP-IV)antagonists.
In addition, the investigators will assess the effect of IL-1 antagonism on insulin and
Glucagon like peptide-1 (GLP-1) secretion as well as muscle soreness,fatigue and vascular
function in response to an acute exercise bout.