Role of Interleukin-6 in Exercise

• Status: Completed
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to understand the role of interleukin-6 during physical activity in patients with type 2 diabetes.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Zurich
• Collaborator: European Foundation for the Study of Diabetes
• Treatments: Sitagliptin Phosphate

Criteria

Inclusion criteria:

• Obesity group: BMI 30-40 kg/m2, fasting plasma glucose <6.4 mmol/l.

• Diabetes group: Type 2 diabetes according to American Diabetes Association criteria

Exclusion criteria:

• Anti-diabetic drug other than metformin

• Diabetes duration of more than 5 years

• Inflammatory diseases

• Current infection

• Liver disease (transaminases >2x upper normal range)

• kidney disease (creatinine >1.5 mg/dl for men and 1.4 mg/dl for women)

• pregnancy or breast-feeding, women of child bearing potential not using an acceptable form of contraception

• immunosuppressive disease

• corticosteroid use

• regular non-steroidal antinflammatory drug usage

• history of carcinoma

• history of tuberculosis

• anemia, bleeding disorders

• obstructive pulmonary disease.