Role of Interleukin (IL)-1 in Postprandial Fatigue - The Chäschüechli 2 Study
Status:
Completed
Trial end date:
2017-04-03
Target enrollment:
Participant gender:
Summary
Role of IL-1 in postprandial fatigue - The Chäschüechli 2 Study It is a randomized, single
dose, placebo-controlled, double blind, cross-over, proof-of-concept study.
16 healthy young men will be included in this study. The objective of this study is to
evaluate if severity of postprandial fatigue is driven by IL-1.
Since fatigue is associated with increased cytokine levels, and since fatigue in chronic
inflammatory settings, such as type 2 diabetes, can be reduced by inhibition of IL-1β,
postprandial fatigue might also respond to anti-inflammatory intervention with IL-1
inhibition.
The aim of the study is to investigate whether postprandial fatigue is, at least in part,
driven by the IL-1 system.