Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis

• Status: Active, not recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract of unknown etiology. UC is characterized by recurring episodes of inflammation limited to mucosal and submucosal layers of the colon. The object of the present study was to determine the prevalence of intestinal protozoa and helminthes in UC patients, and the role of this changes in aetiopathogenesis of diseases. Patients will be examined before and after therapy. Parasites and protozoa prevalence and intensity will be detected by triple coproscopy.Microbiological study will be conducted before therapy for detection pathogenic bacteria only from UC patients infected with B. hominis . If intestinal pathogenic bacteria are found, participants will be excluded from further investigation.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
• Treatments: Mesalamine; Nitazoxanide

Criteria

Inclusion Criteria:

• Patients with ulcerative colitis before therapy and surgery

• Residents of Tashkent region which does not have any complaints from the gastrointestinal tract (control group)

Exclusion Criteria:

• Patients with a diagnosis of Crohn's disease

• Patients with a toxic megacolon,

• Patients with a abdominal abscess, -

• Patients with a symptomatic colonic stricture,

• Patients with a stoma,

• Patients with a a history of colectomy,

• An increased risk of infectious complications (e.g. as a result of recent pyogenic infection, enteric pathogens detected on stool analysis, active or latent tuberculosis, immunodeficiency, hepatitis B or C, or recent live vaccination),

• Clinically meaningful laboratory abnormalities,

• Pregnancy or lactation,

• An unstable or uncontrolled medical disorder,

• An anticipated requirement for major surgery,

• Colonic dysplasia or adenomas,

• Malignant neoplasms.

• Patients which operated,

• Ever used immunosuppressants or biological drugs

• In the presence of pathologic bacteria in gut microbiota, including Clostridium difficile, Salmonella spp, Shigella spp, Campylobacter spp, Yersinia spp, and Mycobacteria.