Role of Intralipid in Management of Organophosphorus Poisoning

• Status: Not yet recruiting
• Trial end date: 2024-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Aim of the study:

To assess the role of intralipid emulsion in the acute man-agement of organophosphorus toxicity and its benefits in de-creasing mortality rates among victims.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Amani Hassan Abdel-Wahab
• Treatments: Atropine; Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria:

• Age group of 18-60 years who are exposed to organophosphorus compounds.

• Clinical manifestations of organophosphorus toxidromes (hyper-salivation, lacrimation, sweating, urinary incontinence, di-arrhea, vomiting and abdominal pain).

Exclusion Criteria:

1. Patient or relative in charge refusal.

2. Chronic renal or liver disease manifested by history, clinical and investigatory diagnosis.

3. Previous history of acute or chronic pancreatitis

4. Combined poisoning with non OP compounds

5. Asymptomatic patients.

6. Contraindications to intralipid emulsion as:

• disturbances of normal fat metabolism such as patho-logic hyperlipemia manifested by history, clinical and investigatory diagnosis.

• lipoid nephrosis manifested by history, clinical and investigatory diagnosis.