Role of L-citrulline in Prevention of Pregnancy Associated Hypertension

• Status: Recruiting
• Trial end date: 2024-07-30
• Target enrollment: 0
• Participant gender: Female

Summary

The target population for our study is healthy nulliparous pregnant women (first pregnancy) between the 12-16 week of pregnancy.

If a subject is eligible, written consent will be obtained by person to person contact. Eligible participants will be randomized to receive either daily L-citrulline supplementation or placebo.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Texas Medical Branch, Galveston

Criteria

Inclusion Criteria:

• Nulliparous (no previous pregnancy greater than 20 weeks)

• Gestational age of pregnancy between 12 and 16 weeks

Exclusion Criteria:

• Known fetal anomaly or chromosomal abnormality

• Early fetal growth restriction

• Fetal demise or planned termination

• Participation in another study that may influence this study

• Known maternal kidney disease

• Known maternal electrolyte imbalance

• Known allergies to study interventions

• Preexisting hypertension (chronic hypertension)

• Known gastric ulcer

• Incarcerated status

• Planned delivery at non-UTMB hospital

• Known lactose intolerance