Role of Liquid Phase Concentrated Growth Factors vs. Hypertonic Dextrose Prolotherapy for Management of Patients With Disc Displacement Without Reduction

• Status: Not yet recruiting
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose of the study is to compare clinically, radiographically and biochemically the effect of intra- articular injection of hypertonic dextrose with a stabilization appliance and the intra- articular injection of 2 ml of liquid phase concentrated growth factor with a stabilization appliance as a prolotherapy for temporomandibular joint anterior disc displacement without reduction.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nourhan M.Aly
• Collaborator: Alexandria University
• Treatments: Mitogens

Criteria

Inclusion Criteria:

• Patients with painful TMJ.

• Patients with limited mouth opening (MMO <40mm).

• Patients with anterior disc displacement without reduction confirmed by MRI.

• Presence of full or nearly full complement of natural teeth.

• Patients with angle class I occlusion.

• Patients with RCP not greater than 2mm and with no open bite.

Exclusion Criteria:

• Patients who have anterior disc dislocation with reduction detected by MRI.

• Inability or unwillingness to undergo magnetic resonance imaging (MRI) such as implanted electronic devices.

• Patients having uncontrolled systemic disease, hematologic or neurologic disorders or inflammatory diseases.

• Patients under anticoagulant drug therapy.