Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine, with Positron Emission Tomography (PET), the role of nitric oxide in the age-associated effect on fatty acid and glucose delivery on myocardial substrate metabolism.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Washington University School of Medicine
• Collaborator: National Institute on Aging (NIA)
• Treatments: NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• Between the ages of 18-35 or 60-75

• Normal glucose tolerance test

• Normal plasma fasting lipid panel (fasting total cholesterol less than 220 mg/dL)

• Normal rest/stress echocardiogram

• BMI (Body Mass Index) less than 30 kg/m2

Exclusion Criteria:

• Coronary artery disease

• High blood pressure

• Current smoker

• Diabetes mellitus

• Cardiovascular disease (signs and symptoms of any kind)

• History of stroke, peripheral vascular disease, or arrhythmia

• Pregnant or breastfeeding